[Shanghai Science and Technology Commission: system layout around basic research and applied basic research such as AI drug design] the Shanghai Science and Technology Commission issued the Shanghai Municipal Action Plan for innovative Development of Computational Biology (2023-2025), which mentioned the system layout around basic and applied basic research such as algorithm development, model building, and AI drug design. Develop original algorithms, models and computing platforms for AI drug research and development, develop large models and generation algorithms for small molecular drugs, establish large models and design platforms for antibody drugs and peptide drugs enhanced by artificial intelligence, develop pharmacological and efficacy prediction models of traditional Chinese medicine prescriptions, and develop modern compound prescriptions with synergistic efficacy.