[Shanghai: preliminary completion of biological big data platform and other infrastructure by 2025] the Shanghai Municipal Commission of Science and Technology issued the Shanghai Action Plan for innovative Development of Computational Biology (2023-2025). Among them, it is proposed that by 2025, a computational biology research paradigm based on modeling, prediction and application should be established, infrastructure such as the big data platform of biology should be initially built, a number of computational biology talents should be trained and introduced, major theoretical breakthroughs should be achieved in the fields of multimodal data theoretical algorithms, protein engineering, and AI drug research and development, and a number of algorithm models and software with independent intellectual property rights and international influence should be developed. Accelerate the emergence of a number of subversive new technologies for life and health, and produce a number of new tools, new standards and new products that can be effectively applied on a large scale, in order to form a dominant discipline in the field of computational biology, to lay the foundation for Shanghai to become a source of innovative ideas, scientific research paradigms and major applications in the field of computational biology.